AAU logo

Center for RNA Medicine

Publications

Selected publications

Guarnerio J, Zhang Y, Cheloni G, Panella R, Mae Katon J, Simpson M, Matsumoto A, Papa A, Loretelli C, Petri A, Kauppinen S, Garbutt C, Petur Nielsen G, Deshpande V, Castillo-Martin M, Cordon-Cardo C, Dimitrios S, Clohessy JG, Batish M, Pandolfi PP. 2019. Intragenic antagonistic roles of protein and circRNA in tumorigenesis. Cell Res. 8: 628-640.

 

Chery J , Petri A, Wagschal A, Lim S-Y, Cunningham J, Vasudevan S, Kauppinen S, and Näär AM. 2018. Development of Locked Nucleic Acid Antisense Oligonucleotides Targeting Ebola Viral Proteins and Host Factor Niemann-Pick C1. Nucleic Acid Ther 28: 273-284.

 

Tsukamoto S, Løvendorf MB, Park J, Salem KZ, Reagan MR, Manier S, Zavidij O, Rahmat M, Huynh D, Takagi S, Kawano Y, Kokubun K, Thrue CA, Nagano K, Petri A, Roccaro AM, Capelletti M, Baron R, Kauppinen S*, and Ghobrial IM*. 2018. Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche. Leukemia 32: 1739-1750. *Co-corresponding authors.

 

Schein A, Zucchelli S, Kauppinen S, Gustincich S, and Carninci P. 2016. Identification of antisense long noncoding RNAs that function as SINEUPs in human cells. Scientific Reports 6: 33605.

 

Petri A, Dybkær K, Bøgsted M, Thrue CA, Hagedorn PH, Schmitz A, Bødker JS, Johnsen HE, and Kauppinen S. 2015. Long noncoding RNA expression during human B-cell development. PLoS One 10: e0138236.

 

van Rooij E*, and Kauppinen S*. 2014. Development of microRNA therapeutics is coming of age. EMBO Mol Med. 6: 851-864. *Co-corresponding authors.

 

Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S*, and Näär AM*. 2013. Pharmacological inhibition of a microRNA family in non-human primates by a seed-targeting 8-mer antimiR. Science Trans Med 5: 212ra162. *Co-corresponding authors.

 

Murphy BL, Obad S, Bihannic L, Ayrault O, Zindy F, Kauppinen S, and Roussel MF. 2013. Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression. Cancer Res. 73: 7068-78.

 

Janssen, HL, Reesink, HW, Lawitz, EJ, Zeuzem, S, Rodriguez-Torres, M, Patel, K, van der Meer, AJ, Patick, AK, Chen, A, Zhou, Y, Persson, R, King, BD, Kauppinen, S, Levin, AA, and Hodges, MR. 2013. Treatment of HCV infection by targeting microRNA. N Engl J Med 368: 1685-94.

 

Lindow M, and Kauppinen S. 2012. Discovering the first microRNA-targeted drug. J Cell Biol. 199: 407-12.

 

Zhang Y, Roccaro AM, Rombaoa C, Flores L, Obad S, Fernandes SM, Sacco A, Liu Y, Ngo H, Quang P, Azab AK, Azab F, Maiso P, Reagan M, Brown JR, Thai TH, Kauppinen S, and Ghobrial IM. 2012. LNA-mediated anti-miR-155 silencing in low-grade B-cell lymphomas. Blood 120: 1678-86.

 

Stenvang J, Petri A, Lindow M, Obad S, and Kauppinen S. 2012. Inhibition of microRNA function by antimiR oligonucleotides. Silence 3:1.

 

Garchow BG, Encinas OB, Leung YT, Tsao PY, Eisenberg RA, Caricchio R, Obad S, Petri A, Kauppinen S, and Kiriakidou M. 2011. Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice. EMBO Mol. Med. 10: 605-15.

 

Eskildsen T, Taipaleenmäki H, Stenvang J, Abdallah BM, Ditzel N, Nossent AY, Bak M, Kauppinen S, and Kassem M. 2011. MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo. Proc. Natl. Acad. Sci. USA 108: 6139-44.

 

Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, Hansen HF, Koch T, Pappin D, Hannon GJ, and Kauppinen S. 2011. Silencing of microRNA families by seed-targeting tiny LNAs. Nat. Genet. 43: 371-8.

 

Castoldi M, Vujic Spasic M, Altamura S, Elmén J, Lindow M, Kiss J, Stolte J, Sparla R, D'Alessandro LA, Klingmüller U, Fleming RE, Longerich T, Gröne HJ, Benes V, Kauppinen S, Hentze MW, and Muckenthaler MU. 2011. The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J. Clin. Invest. 121: 1386-96.

 

Patrick DM, Montgomery RL, Qi X, Obad S, Kauppinen S, Hill JA, van Rooij E, and Olson EN. 2010. Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice. J. Clin. Invest. 120: 3912-6.

 

Liu X, Sempere LF, Ouyang H, Memoli VA, Andrew AS, Luo Y, Demidenko E, Korc M, Shi W, Preis M, Dragnev KH, Li H, Direnzo J, Bak M, Freemantle SJ, Kauppinen S, and Dmitrovsky E. 2010. MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. J. Clin. Invest. 120: 1298-309.

 

Lanford RE, Hildebrandt-Eriksen ES, Petri A, Persson R, Lindow M, Munk ME, Kauppinen S, and Ørum H. 2010. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 327: 198-201.

 

Worm J, Stenvang J, Petri A, Frederiksen KS, Obad S, Elmén J, Hedtjärn M, Straarup EM, Hansen JB, and Kauppinen S. 2009. Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF. Nucleic Acids Res. 37: 5784-92.

 

Siegel G, Obernosterer G, Fiore R, Oehmen M, Bicker S, Christensen M, Khudayberdiev S, Leuschner PF, Busch CJ, Kane C, Hübel K, Dekker F, Hedberg C, Rengarajan B, Drepper C, Waldmann H, Kauppinen S, Greenberg ME, Draguhn A, Rehmsmeier M, Martinez J, and Schratt GM. 2009. A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat. Cell Biol. 11: 705-16.

 

Kocerha J, Faghihi MA, Lopez-Toledano MA, Huang J, Ramsey AJ, Caron MG, Sales N, Willoughby D, Elmen J, Hansen HF, Orum H, Kauppinen S, Kenny PJ, and Wahlestedt C. 2009. MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. Proc. Natl. Acad. Sci. USA 106: 3507-12.

 

Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, and De Strooper B. 2008. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc. Natl. Acad. Sci. USA 105: 6415-20.

 

Kauppinen S, and Havelda Z. 2008. Detection of siRNAs and miRNAs. Methods Mol. Biol. 451: 217-27.

 

Elmén J, Lindow M, Schütz S, Lawrence M, Petri A, Obad S, Lindholm M, Hedtjärn M, Hansen HF, Berger U, Gullans S, Kearney P, Sarnow P, Straarup EM, and Kauppinen S. 2008. LNA-mediated microRNA silencing in non-human primates. Nature 452: 896-9.

 

Silahtaroglu AN, Nolting D, Dyrskjøt L, Berezikov E, Møller M, Tommerup N, and Kauppinen S. 2007. Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification. Nat. Protoc. 2: 2520-8.

 

Kloosterman WP, Wienholds E, de Bruijn E, Kauppinen S, and Plasterk RH. 2006. In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes. Nat. Methods 3: 27-9.

 

Wienholds E, Kloosterman WP, Miska E, Alvarez-Saavedra E, Berezikov E, de Bruijn E, Horvitz HR, Kauppinen S, and Plasterk RH. 2005. MicroRNA expression in zebrafish embryonic development. Science 309: 310-1.